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Association between Fine Particulate Matter Exposure and Cerebrospinal Fluid Biomarkers of Alzheimer’s Disease among a Cognitively Healthy Population-Based Cohort

Summary

A study published in Environmental Health Perspectives investigated the link between long-term exposure to fine particulate matter (PM2.5) and cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) among a group of cognitively healthy adults aged 45–75. The research found that increased exposure to PM2.5 over 1-year, 3-year, and 5-year periods was associated with decreased CSF β-amyloid (β) concentrations, a hallmark of AD. This suggests a potential role for PM2.5 in the accumulation of amyloid plaques in the brain, increasing the risk of developing AD. The study highlights the importance of understanding environmental factors, such as air pollution, in the context of neurodegenerative diseases like Alzheimer's, emphasizing the need for further research in this area to inform public health policies aimed at reducing disease burden.

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